Mapiritsi pakali pano ndi amodzi mwa mawonekedwe omwe amagwiritsidwa ntchito kwambiri, omwe amatuluka kwambiri komanso omwe amagwiritsidwa ntchito kwambiri.Njira yonyowa yonyowa ikadali njira yayikulu yopangira mankhwala.Ili ndi njira zopangira okhwima, mtundu wabwino wa tinthu, magwiridwe antchito apamwamba, komanso psinjika akamaumba.Zabwino ndi zina zabwino, ndizomwe zimagwiritsidwa ntchito kwambiri pamakampani opanga mankhwala.
Njira yopangira mapiritsi imatha kugawidwa m'magulu azinthu zopangira komanso zothandizira, kuyeza, granulating, kuyanika, kusakaniza, mapiritsi, kupaka, etc. ndi kulongedza ndi mchira wa Phoenix, zikhoza kuwoneka kuti ndondomeko ya granulation imagwira ntchito yofunika kwambiri pakupanga mapiritsi onse, koma momwe mungapangire zipangizo zofewa ndi kupeza ma granules, mpaka pano pali tanthauzo lakuya kwambiri m'mabuku "ogwira mpira, kugwira ndi kubalalitsa” , Sizinafotokozedwe.Kutengera zomwe wolembayo adakumana nazo pakupanga kwenikweni, nkhaniyi ikuwunika zinthu zingapo zomwe zimakhudzidwa ndi kukhazikika kwa piritsi yonyowa granulation, ndipo ikupereka njira zoyenera zowongolera kuti zitsimikizire mtundu wa kupanga mankhwala.
Prepreatment wa zipangizo
Zida zopangira ndi zothandizira nthawi zambiri zimafunikira kuphwanyidwa ndikuwunika musanasakanizidwe konyowa ndi kupanga granulation.Zochitika zina zosayenera zomwe zimachitika nthawi zambiri pamapiritsi, monga kusakanikirana kosagwirizana, kugawanika, kumamatira kapena kusungunuka, ndi zina zotero, zimagwirizana kwambiri ndi kusakwanira kwa pulverization fineness ya zipangizo panthawi yokonzekera.Ngati zopangirazo zili zomangira kapena makristasi ooneka ngati singano, kuthekera kwa kupatuka pamwambaku kudzakhala koonekeratu.Chophimba cha pretreatment, kuphwanya ndi kusefa mwachikhalidwe nthawi zambiri chimakhala 80 mesh kapena 100 mesh screen, koma ndikupita patsogolo kwa zida ndi ukadaulo wazinthu zopangira, zida zambiri zomwe zidaphwanyidwa kudzera pazenera la 80 mesh mwachikhalidwe. tsopano akhoza kupitirira 100. Kuthekera kwa chochitika pamwambapa kumachepetsedwa kwambiri kwa ufa wabwino womwe waphwanyidwa kupyolera mu sieve ya 100-mesh.Choncho, ubwino wa zipangizo zaiwisi ndi zothandizira kupyolera mu sieve ya 100-mesh pang'onopang'ono m'malo mwa 80-mesh sieving process.
Kuyeza
Chifukwa kuwonjezeka kapena kuchepa kwa kulemera kwa chinthu chilichonse kumayambitsa kusintha kotsatira muzochitika zina za ndondomeko, zomwe zingayambitse kusakhazikika kwa tinthu tating'onoting'ono, zomwe zingayambitse mavuto angapo monga mapiritsi a piritsi, friability kwambiri, kupasuka pang'onopang'ono kapena kuchepetsa. Kusungunuka, kotero nthawi iliyonse mukadyetsa Ndalama sizingasinthidwe mosasamala.Muzochitika zapadera, kulemera kwake kuyenera kutsimikiziridwa molingana ndi ndondomeko yotsimikizirika.
Kukonzekera kwa particles
Masiku ano, granulator yonyowa yothamanga kwambiri ndiye zida zomwe zimagwiritsidwa ntchito kwambiri popanga granulation.Poyerekeza ndi chosakanizira chachikhalidwe ndi granulator, granulator yamtunduwu imakhala chifukwa cha vuto lamankhwala osiyanasiyana kapena kufunafuna zapamwamba.Choncho, granulator sichimachotsedwa, ndipo granulator yothamanga kwambiri yonyowa imangogwiritsidwa ntchito ngati chosakaniza chachikhalidwe, ndiyeno ma granules ochulukirapo amapezeka kudzera mu granulation.Njira zomwe zimakhudza ubwino wa granules zonyowa makamaka zimaphatikizapo zinthu zambiri monga kutentha, mlingo, kuwonjezera njira ya binder, kuthamanga ndi kudula kwa granulator, ndi nthawi yogwedeza ndi kudula.
Kutentha kwa zomatira
Kutentha kwa zomatira ndiye chizindikiro chovuta kwambiri chowongolera pakupanga masikelo.Ndizosatheka kuwongolera molondola kusasinthasintha kwa kutentha musanawonjezere zomatira nthawi zonse.Choncho, mitundu yambiri sidzagwiritsa ntchito kutentha monga cholozera chowongolera, koma popanga zenizeni, zimapezeka kuti kutentha kwa starch slurry kumakhudza kwambiri mitundu ina yapadera.Kwa mitundu iyi, kutentha kumafunika momveka bwino.Nthawi zambiri, kutentha kumakhala kokwera.The apamwamba otsika adhesion, m'munsi friability piritsi;kumtunda kwa wowuma slurry kutentha, kutsika kumamatira, komanso kusungunuka kwa piritsi.Choncho, m'njira zina zomwe zimagwiritsa ntchito starch slurry ngati chomangira, kutentha kwa binder kuyenera kuyendetsedwa pamlingo wina.
Kuchuluka kwa zomatira
Kuchuluka kwa binder kumakhala ndi zotsatira zoonekeratu pazitsulo zonyowa, choncho kuchuluka kwake kumagwiritsidwanso ntchito ngati chinthu chofunika kwambiri chowongolera.Nthawi zambiri, kuchuluka kwa binder kumapangitsa kuti kachulukidwe ndi kuuma kwa tinthu ting'onoting'ono kukhale kokulirapo, koma kuchuluka kwa binder nthawi zambiri kumasiyanasiyana malinga ndi kuchuluka kwa zida zopangira komanso zothandizira.Padzakhalanso kusintha pang'ono kusiyana pakati pa mitundu yosiyanasiyana, yomwe imayenera kusonkhanitsa nthawi yayitali yopanga molingana ndi mitundu yosiyanasiyana.Pofuna kukonza zolimba za zipangizo zofewa, mkati mwazomveka, njira yowonjezera kuchuluka kwa binder ndi yabwino kuposa njira yowonjezera nthawi yosakaniza.
Kukhazikika kwa zomatira
Nthawi zambiri, kuchuluka kwa zomatira kumapangitsanso kukhuthala kwakukulu, komwe sikungasiyanitsidwe ndi mlingo wake.Opanga ambiri sangasankhe kusintha ndende akapeza zomatira pambuyo potsimikizira, koma kuwongolera zinthu zofewa posintha kuchuluka kwa zomatira, nthawi zambiri kumangiriza Kuphatikizika kwa wothandizila kudzalembedwa ngati mtengo wokhazikika mu ndondomeko ya ndondomeko ndipo osagwiritsidwa ntchito kusintha mtundu wa tinthu tonyowa, kotero sindingabwereze pano.
Momwe mungawonjezere zomatira
Gwiritsani ntchito makina ophatikizira onyowa othamanga kwambiri kuti mupange granulate.Kawirikawiri, pali njira ziwiri zowonjezera binder.Chimodzi ndikuyimitsa makinawo, kutsegula chivundikiro cha granulator, ndikutsanulira chomangiracho mwachindunji.Mwa njira imeneyi, binder si kophweka kumwazikana, ndi granulation ndi Nthawi zina n'zosavuta chifukwa mkulu m'deralo ndende ndi m'goli tinthu kukanika.Chotsatira chake ndi chakuti mapiritsi otulutsidwa amatha kusokoneza kapena kusungunula kusiyana kwakukulu;chinacho ndi chosayima, pogwiritsa ntchito chomangira chodyera, kutsegula valavu yodyetsera, ndi kusonkhezera.Kuwonjezera pa ndondomekoyi, njira yodyetserayi ingapewe kusagwirizana kwapafupi ndi kupanga tinthu tating'ono ting'onoting'ono.Komabe, chifukwa cha zofunikira za mtundu wa binder, mapangidwe a zida kapena machitidwe ogwiritsira ntchito, ndi zina zotero, zimalepheretsa kugwiritsa ntchito njira yachiwiri yopangira slurrying.ntchito.
Kusankha kwa liwiro losakaniza ndi liwiro la kudula
Maonekedwe a zinthu zofewa panthawi ya granulation amagwirizana mwachindunji ndi kusankha kwa kugwedeza ndi kudula liwiro la granulator yosakanikirana yothamanga kwambiri, yomwe imakhudza kwambiri khalidwe la pellets, ndipo imakhudza mwachindunji ubwino wa mapiritsi otulutsidwa.Pakali pano, choyambitsa galimoto ya mkulu-liwiro chonyowa kusakaniza granulator ali mawilo awiri ndi variable pafupipafupi liwiro lamulo.Kuthamanga kwawiri kumagawidwa kukhala otsika komanso kuthamanga kwambiri.Kuwongolera pafupipafupi kutembenuka kwa liwiro kumagwiritsa ntchito kuwongolera liwiro lamanja, koma kuwongolera liwiro lamanja kudzakhudza particles kumlingo wina.Choncho, mkulu-liwiro kusanganikirana granulator ndi pafupipafupi kutembenuka liwiro lamulo zambiri amaika kusakaniza liwiro ndi kuthamanga nthawi, ndi kuyamba basi ntchito pulogalamu kuchepetsa kusiyana kwa anthu.Kwa mitundu yamtundu uliwonse, kutembenuka kwafupipafupi kumagwiritsidwabe ntchito ngati liwiro lawiri, koma kwa mitundu ina yapadera, yomwe ikugwira ntchito nthawi yomweyo, mutha kuwonjezera liwiro kuti mupeze zinthu zofewa zolimbitsa thupi, kuti mupewe kusakanikirana kwanthawi yayitali zinthu zofewa zothina kwambiri.
Kusankha kusakaniza ndi kuphwanya nthawi
Njira yowonongeka yomwe imakhudza ubwino wa zipangizo zofewa ndi nthawi ya kusakaniza ndi kuphwanya.Kuyika kwa magawo ake kumatsimikizira mwachindunji kupambana kapena kulephera kwa ndondomeko ya granulation.Ngakhale kuti kuthamanga kwa kusakaniza ndi kuthamanga kungathe kusinthidwa ndi kutembenuka kwafupipafupi, njira zambiri zopangira ndondomeko zimakhazikika Kuti muchepetse kusiyana, kuti mupeze zinthu zofewa zoyenera, sankhani kupeza zinthu zofewa zoyenera mwa kusintha nthawi.Muzochitika zachilendo, kusakaniza kochepa ndi nthawi yochepetsera kudzachepetsa kuchulukira, kuuma, ndi kufanana kwa tinthu tating'onoting'ono, ndi ming'alu ndi kufanana kosagwirizana panthawi ya tableting;Kusakaniza kotalika kwambiri ndi nthawi yowonongeka kumayambitsa kachulukidwe ndi kuuma kwa tinthu tating'onoting'ono Ngati tawonjezereka, zinthu zofewa zimatha kulephera panthawi ya mapiritsi, nthawi ya kupasuka kwa piritsiyo idzakhala yaitali, ndipo chiwerengero cha kusungunuka sichidzakhala choyenera.
Zida za granulation ndi njira za granulation
Pakadali pano, kusankha kwa zida zopangira granulation zonyowa zimagawika m'magulu angapo ogwiritsira ntchito granulator ndi swing granulator.Ubwino wa multifunction granulator ndikuchita bwino komanso kosavuta kugwiritsa ntchito.Choyipa chake ndi kusiyana kwa kuchuluka ndi liwiro la kudyetsa chifukwa cha kudyetsa pamanja., Kufanana kwa tinthu tating'onoting'ono toyipa pang'ono;ubwino wa swing mtundu granulator ndi kuti granules ndi yunifolomu, ndi kusiyana Buku kudyetsa kuchuluka ndi kudyetsa liwiro ndi ochepa.Choyipa ndichakuti magwiridwe antchito ndi otsika ndipo kugwiritsa ntchito zowonera zotayidwa kumagwiritsidwa ntchito kugwetsa.Kuyika kumakhala kovuta.Kukula kwa tinthu ting'onoting'ono kumatha kuyambitsa kusiyana kupitilira malire.Nambala ya mauna ndi liwiro la zenera lonse la tinthu zitha kuwongoleredwa kuti ziwongolere.Nthawi zambiri, ngati zonyowa particles ndi zothina, mukhoza kuganizira kuwonjezera liwiro, kusankha lalikulu chophimba, ndi kuchepetsa kuchuluka kwa chakudya nthawi iliyonse.Ngati particles ali lotayirira, mukhoza kuganizira kuchepetsa liwiro, kusankha ang'onoang'ono chophimba, ndi kuwonjezera kuchuluka kwa chakudya nthawi iliyonse.Kuonjezera apo, posankha zowonetsera, nthawi zambiri pamakhala zowonetsera zitsulo zosapanga dzimbiri ndi zojambula za nayiloni zomwe mungasankhe.Malinga ndi luso la kupanga ndi zinthu zofewa, ndi bwino kusankha zowonetsera zitsulo zosapanga dzimbiri za viscous zofewa, ndi zouma zofewa.Chophimba cha nayiloni ndichoyenera kwambiri, ndipo granulator yamtundu wa swing imathanso kuganizira za kulimba kwa chotchinga kuti isinthe kuti ipeze tinthu tating'ono.``
Zouma
The mwachilengedwe mafanizidwe a kuyanika kwenikweni ndi tinthu chinyezi.The tinthu chinyezi ndi yofunika kuunika chinthu cha khalidwe la particles.Kuwongolera koyenera kwa chizindikiro ichi kumakhudza mwachindunji mawonekedwe ndi friability ya piritsi panthawi ya piritsi.Munthawi yanthawi zonse, kugunda kwapang'onopang'ono kumatha kuganiziridwa ngati kumachitika chifukwa cha chinyezi chochepa, ndipo ngati kumamatira kumachitika panthawi ya mapiritsi, ndikofunikira kulingalira ngati kumayamba chifukwa cha chinyezi chambiri.Mlozera wowongolera wa chinyezi cha tinthu nthawi zambiri umatsimikiziridwa potsimikizira ndondomeko, koma chinyezi nthawi zambiri chimakhala chovuta kuchulukitsa, ndipo pamafunika kusonkhanitsa deta ndikupanga mtundu wowongolera chinyezi.Njira zambiri zoyanika zachikhalidwe zimagwiritsa ntchito kuyanika kowiritsa.Zomwe zimakhudzidwa zimaphatikizira magawo azinthu monga kuthamanga kwa nthunzi, kutentha kwa kuyanika, nthawi yowumitsa, ndi kulemera kwa tinthu tating'onoting'ono touma.Chinyezi cha tinthu tating'onoting'ono timayendetsedwa ndi chowunikira mwachangu cha chinyezi.Wogwira ntchito waluso amatha kudutsa nthawi yayitali.Pochita kupanga, chinyezi chamtundu uliwonse wowumitsa chimayendetsedwa munjira yoyenera, yomwe imatha kuwongolera bwino kupanga komanso kuwongolera chinyezi.Kuwonjezera zinachitikira yaitali, pachimake deta gwero ndi kuyanika nthawi ndi zouma zipangizo kutentha.
Lonse granulation youma granules
Chimodzimodzinso ndi granulation yonyowa ndikuti magawo omwe amakhudza mtundu wa ma granules owuma nthawi zambiri amakhala nambala ya mauna ndi liwiro la chinsalu chonse cha granulation.Pofuna kuonetsetsa kuti yosalala kupanga pa tableting, kupeza abwino kwambiri tinthu kukula kugawa.Uwu ndi mwayi womaliza wosintha., Posankha ma meshes osiyanasiyana ndi liwiro lozungulira, zidzakhudza kwambiri particles zouma.Nthawi zambiri, tinthu tating'onoting'ono tating'ono, sankhani chophimba chaching'ono, ndipo tinthu tating'onoting'ono tating'ono, sankhani chophimba chachikulu.Komabe, muzochitika zodziwika bwino, izi sizidzakhala kusankha kwa njira yokhwima.Ngati mukufuna kupeza particles bwino, muyenera kuphunzira ndi kukonza ndondomeko yokonza zofewa.
Kusakaniza
The kusanganikirana ndondomeko magawo zimene zimakhudza tinthu khalidwe zambiri kuchuluka kwa osakaniza, liwiro la chosakanizira, ndi nthawi kusanganikirana.Kuchuluka kwa kusakaniza ndi mtengo wokhazikika pambuyo potsimikizira ndondomekoyi.Kuthamanga kwa chosakaniza kungakhudzidwe ndi kuthamanga kwa liwiro la chosakaniza chifukwa cha kuvala kwa zipangizo.Kufanana kwa kusanganikirana kumafuna kuyang'anitsitsa kwa zida ndi nthawi ndi nthawi kutsimikizira zida zisanachitike.Pofuna kuonetsetsa kufanana kwa tinthu kusanganikirana kwambiri ndi kupeza yunifolomu khalidwe mankhwala, m'pofunika kupeza kusakaniza nthawi mwa ndondomeko yachinsinsi.Zokwanira kusanganikirana nthawi ndi chitsimikizo ogwira kuonetsetsa mlingo wa kubalalitsidwa kwa lubricant mu particles youma, mwinamwake lubricant adzapanga electrostatic adsorption magulu pa kusanganikirana youma particles, zomwe zidzakhudza khalidwe la particles.
Ndemanga:
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Nthawi yotumiza: Apr-20-2021